Nanofabricated upconversion nanoparticles for photodynamic therapy.
نویسندگان
چکیده
We present a novel process for the production of three-layer Composite Nanoparticles (CNPs) in the size range 100-300 nm with an up-converting phosphor interior, a coating of porphyrin photosensitizer, and a biocompatible PEG outer layer to prevent clearance by the reticuloendothelial system. We show that these CNPs produce millimolar amounts of singlet oxygen at NIR intensities far less than other two-photon techniques.
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عنوان ژورنال:
- Optics express
دوره 17 1 شماره
صفحات -
تاریخ انتشار 2009